IL7 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 1:500 - 1:2000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human IL7
Formulation	Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	interleukin 7
Database Link	NP_000871 Entrez Gene 16196 MouseEntrez Gene 25647 RatEntrez Gene 3574 Human UniProt ID P13232
Background	IL-7 plays a key role in lymphopoiesis and lymphoid homeostasis . Stromal and epithelial cells within the bone marrow and thymus produce IL-7 (1). The primary targets of IL-7 are T cells, B cells, and dendritic cells . IL-7 is crucial for T cell development, the importance of which is underscored by the lack of T cells in both mice and humans that are deficient in IL-7/IL-7R signaling . While IL-7 appears to be required for B cell development in mice, the role of IL-7 in human B cell development is unclear . In addition to its effects on T cell lymphopoiesis, IL-7 promotes the maintenance and survival of naïve and memory aβ T cells, as well as ?d T cells . The IL-7 receptor is a heterodimer of the common ? chain, ?c, and the IL-7-specific IL-7Ra . IL-7 activates PI3K/Akt, Jak1/2, and Stat1, 3, and 5 .
Synonyms	IL-7
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway

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