Galectin 3 (LGALS3) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, WB
Recommend Dilution	WB 1:500 - 1:2000;IF 1:50- 1:200
Reactivity	Human, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human LGALS3
Formulation	Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	lectin, galactoside binding soluble 3
Database Link	NP_002297 Entrez Gene 83781 RatEntrez Gene 3958 Human UniProt ID P17931
Background	Galectins are a family of soluble b-galactoside-binding animal lectins that modulate cell-to-cell adhesion and cell-to-extracellular matrix (ECM) inter- actions and play a role in tumor progression, pre-mRNA splicing and apop-tosis. The galectin-3 protein, also known as Mac-2, hMac-2, GALBP, CBP35 or LGALS3, contains a single carbohydrate binding domain, which binds galactose-containing glycoconjugates. Galectin-3 is expressed in colonic and intestinal epithelium, inflammatory macrophages, papillary and follicular carcinomas, neoplastic astrocytes and some B and T lymphocytes. Upregulated expression of galectin-3 is involved in cancer progression and metastasis. Galectin-3 mediates the endocytosisof ?1 Integrins in a lactose-dependent manner and is associated with thyroid malignancy and Crohn’s diseasedisease. It may also be used as a marker for diagnosing cases involving Hurthle cell adenomas and carcinomas.
Synonyms	CBP35; GAL3; GALBP; GALIG; L31; LGALS2; MAC2
Reference Data
Protein Families	Secreted Protein

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