PSMA3 Rabbit Polyclonal Antibody

CAT#: TA327024

PSMA3 Rabbit Polyclonal Antibody



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CNY 1,999.00

CNY 2,700.00


货期*
2周

规格
    • 100 ul

Product images

经常一起买 (5)
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Transient overexpression lysate of proteasome (prosome, macropain) subunit, alpha type, 3 (PSMA3), transcript variant 2
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Recombinant protein of human proteasome (prosome, macropain) subunit, alpha type, 3 (PSMA3), transcript variant 1, 100 µg
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Transient overexpression lysate of proteasome (prosome, macropain) subunit, alpha type, 3 (PSMA3), transcript variant 1
    • 100 ug

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Specifications

Product Data
Applications IHC, IP, WB
Recommend Dilution WB 1:500 - 1:2000
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Recombinant protein of human PSMA3
Formulation Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration lot specific
Purification Affinity purification
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name proteasome subunit alpha 3
Background The 20S proteasome is the major proteolytic enzyme complex involved in intracellular protein degradation. It consists of four stacked rings, each with seven distinct subunits. The two outer layers are identical rings composed of a subunits (called PSMAs), and the two inner layers are identical rings composed of β subunits. While the catalytic sites are located on the β rings, the a subunits are important for assembly and as binding sites for regulatory proteins. Seven different a and ten different β proteasome genes have been identified in mammals. PA700, PA28, and PA200 are three major protein complexes that function as activators of the 20S proteasome. PA700 binds polyubiquitin with high affinity and associates with the 20S proteasome to form the 26S proteasome, which preferentially degrades poly-ubiquitinated proteins. The proteasome has a broad substrate spectrum that includes cell cycle regulators, signaling molecules, tumor suppressors, and transcription factors. By controlling the degradation of these intracellular proteins, the proteasome functions in cell cycle regulation, cancer development, immune responses, protein folding, and disease progression.
Synonyms HC8; PSC3
Reference Data
Protein Families Druggable Genome, Protease, Stem cell - Pluripotency
Protein Pathways Proteasome
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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