TGF beta receptor associated protein 1 (TGFBRAP1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	SDHD antibody was raised against a 15 amino acid synthetic peptide near the center of human SDHD.
Formulation	SDHD Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	SDHD Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	transforming growth factor beta receptor associated protein 1
Database Link	NP_002993 Entrez Gene 9392 Human UniProt ID O14521
Background	SDHD Antibody: The mitochondrial succinate dehydrogenase complex subunit D (SDHD) is one of four proteins that make up the tricarboxylic cycle enzyme succinate dehydrogenase (SCH). Studies have shown that mutations in SDHD often leads to hereditary paragangliomas, usually benign tumors of the autonomic nervous system, suggesting that SDHD also plays a role as a tumor-suppressor gene. In one family with a nonsense mutation (R22X) in the SDHD gene, a loss of heterozygosity was found in the paragangliomas, and within these tumors the enzymatic activity of Complex II in the mitochondrial respiratory chain was completely abolished. Furthermore, high levels of angiogenic factors EPAS1 and VEGF was observed, which may stimulate tumor growth.
Synonyms	CBT1; CII-4; CWS3; cybS; PGL; PGL1; QPs3; SDH4
Reference Data

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