Haptoglobin (HP) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 200-1000 WB positive control: Human brain gliomas tissue IHC: 25-100 Positive control: Human lung cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 162-406 amino acids of human haptoglobin
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	45 kDa
Gene Name	haptoglobin
Database Link	NP_001119574 Entrez Gene 15439 MouseEntrez Gene 24464 RatEntrez Gene 3240 Human UniProt ID P00738
Background	This gene encodes a preproprotein; which is processed to yield both alpha and beta chains; which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin; which allows degradative enzymes to gain access to the hemoglobin; while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy; the incidence of coronary artery disease in type 1 diabetes; Crohn's disease; inflammatory disease behavior; primary sclerosing cholangitis; susceptibility to idiopathic Parkinson's disease; and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms	BP; HP2ALPHA2; HPA1S
Reference Data
Protein Families	Druggable Genome, Protease, Secreted Protein, Transmembrane

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