MRP1 (ABCC1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 200-1000 WB positive control: HepG2 and LO2 cell IHC: 20-100 Positive control: Human liver cancer Predicted cell location: Cytoplasm and Cell membrane
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 625-638 amino acids of human ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	173 kDa
Gene Name	ATP binding cassette subfamily C member 1
Database Link	NP_004987 Entrez Gene 4363 Human UniProt ID P33527
Background	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1; MDR/TAP; MRP; ALD; OABP; GCN20; White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter; with oxidized glutatione; cysteinyl leukotrienes; and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown.
Synonyms	ABC29; ABCC; GS-X; MRP; MRP1
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	ABC transporters

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