14 3 3 gamma (YWHAG) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1000-5000 WB positive control: 293T and Jurkat cells IHC: 50-200 Positive control: Human lung cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 141-154 amino acids of Human tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	28 kDa
Gene Name	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
Database Link	NP_036611 Entrez Gene 22628 MouseEntrez Gene 56010 RatEntrez Gene 7532 Human UniProt ID P61981
Background	This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals; and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells; and is also highly expressed in skeletal and heart muscles; suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C; proteins involved in various signal transduction pathways.
Synonyms	14-3-3GAMMA; PPP1R170
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Cell cycle, Neurotrophin signaling pathway, Oocyte meiosis

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