AGR3 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1000-5000 WB positive control: A549 cell, HT-29 cell, Human next to colon cancer tissue lysates IHC: 50-200 Positive control: Human thyroid cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 22-166 amino acids of human anterior gradient 3 homolog (Xenopus laevis)
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	19 kDa
Gene Name	anterior gradient 3, protein disulphide isomerase family member
Database Link	NP_789783 Entrez Gene 403205 MouseEntrez Gene 155465 Human UniProt ID Q8TD06
Background	Anterior gradient protein 3 homolog?is a?protein?that in humans is encoded by the?AGR3?gene. The deduced 166-amino acid protein has an N-terminal signal sequence. Fluorescence-tagged BCMP11 localized in secretory or endosome-like organelles in transfected breast carcinoma cell lines. Immunohistochemical analysis showed that expression of BCMP11 was restricted in normal tissues, with significant staining of only the epithelial lining of colonic mucosa. However, BCMP11 was detected in 43 of 58 (74%) breast cancer tissues tested, but not in normal breast ductal epithelial cells. In cancerous epithelial cells, BCMP11 localized to the cytoplasm.
Synonyms	AG-3; AG3; BCMP11; hAG-3; HAG3; PDIA18
Reference Data
Protein Families	Secreted Protein

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