Melatonin Receptor 1A (MTNR1A) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: SP20 cell lysate IHC: 30-150 Positive control: Human colorectal cancer Predicted cell location: Cell membrane
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide peptide corresponding to a region derived from 130-144 amino acids of human melatonin receptor 1A
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	39 kDa
Gene Name	melatonin receptor 1A
Database Link	NP_005949 Entrez Gene 17773 MouseEntrez Gene 114211 RatEntrez Gene 4543 Human UniProt ID P48039
Background	This gene encodes one of two high affinity forms of a receptor for melatonin; the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled; 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.
Synonyms	MEL-1A-R; MT1
Reference Data
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	Neuroactive ligand-receptor interaction

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