LOX Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Human leiomyosarcoma tissue IHC: 25-100 Positive control: Human lung cancer Predicted cell location: Cytoplasm, ExtraCellular space
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 326-339 amino acids of Human lysyl oxidase
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	47 kDa
Gene Name	lysyl oxidase
Database Link	NP_002308 Entrez Gene 16948 MouseEntrez Gene 24914 RatEntrez Gene 4015 Human UniProt ID P28300
Background	The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene.
Synonyms	MGC105112
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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