TBK1 Goat Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1-3ug/ml, ELISA: 1:128,000
Reactivity	Human
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence C-TIETSLQDIDSRLS, from the C or N Terminus of the protein sequence according to NP_037386.1
Formulation	Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Concentration	lot specific
Purification	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	83.6 kDa
Gene Name	TANK binding kinase 1
Database Link	NP_037386 Entrez Gene 29110 Human UniProt ID Q9UHD2
Background	The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. [provided by RefSeq, Oct 2010]
Synonyms	NAK; T2K
Note	Approx 85kDa band observed in lysates of cell line HeLa (calculated MW of 83.6kDa according to NP_037386.1). Recommended concentration: 1-3µg/ml. An additional band of unknown identity was also consistently observed at 24kDa. This band was successfully blocked by incubation with the immunizing peptide.
Reference Data
Protein Families	Druggable Genome, Protein Kinase
Protein Pathways	Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway

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