CREB1 Rabbit Polyclonal Antibody

CAT#: TA319433

Rabbit polyclonal CREB phospho S133 antibody (Phospho-specific)



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CNY 8,025.00


货期*
5周

规格
    • 100 ul

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Specifications

Product Data
Applications IHC, WB
Recommend Dilution ELISA: 1:1,000 - 1:6,000, WB: 1:500 - 1:2,000, IHC: 20 ug/ml
Reactivity Human, Mouse, Rat
Modifications Phospho-specific
Host Rabbit
Clonality Polyclonal
Immunogen CREB phospho peptide corresponding to amino acid residues 122-147 of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH).
Formulation 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Concentration lot specific
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name cAMP responsive element binding protein 1
Synonyms CREB
Note The CREB (Cyclic AMP-response-element-binding-protein 1) gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element (CRE element TGANNTCA), an octameric palindrome. Phosphorylation by cAMP-dependent protein kinase (PKA) at serine-119 is required for interaction with DNA and phosphorylation at serine-133 allows CREB to interact with CBP (CREB binding protein) leading to interaction with RNA polymerase II. Alternate splicing of this gene results in two transcript variants encoding different isoforms.
Reference Data
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Antigen processing and presentation, Huntington's disease, Melanogenesis, Prostate cancer
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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