LOX Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, IHC, Simple Western, WB
Recommend Dilution	Immunohistochemistry: 1:200, Simple Western: 1:100, Immunocytochemistry/ Immunofluorescence: 1:100, Western Blot: 1:500-1:1000, Immunohistochemistry-Paraffin: 1:200
Reactivity	Human, Mouse, Rat, Porcine, Cow
Host	Rabbit
Clonality	Polyclonal
Immunogen	A cocktail of two synthetic peptides; one made to a region of the human LOX protein within residues 300-400 and one within residues 200-300
Formulation	Tris-glycine, 150mM NaCl and 0.02% sodium azide
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	lysyl oxidase
Database Link	NP_002308 Entrez Gene 16948 MouseEntrez Gene 24914 RatEntrez Gene 4015 Human UniProt ID P28300
Background	Lysyl oxidase (LOX), a copper-containing amine oxidase, belongs to a heterogeneous family of enzymes that oxidize primary amine substrates to reactive aldehydes. It plays a vital role in the formation and repair of the extracellular matrix. In addition, LOX is a multifunctional enzyme having diverse biological functions such as developmental regulation, tumor suppression, cell motility, and cellular senescence. The secreted form of LOX is responsible for the invasive properties of hypoxic human cancer cells. Thus, it is essential for hypoxia-induced metastasis and is a good therapeutic target for preventing and treating metastases.
Synonyms	MGC105112
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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