IDO1 Sheep Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western Blot: 1/1000. Immunohistochemistry on Paraffin Sections: This antibody requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH6.0 is recommended for this purpose. Does not work on Frozen Sections.
Reactivity	Human
Host	Sheep
Clonality	Polyclonal
Immunogen	Recombinant human indoleamine 2,3-dioxygenase.
Specificity	This antibody recognises Indoleamine 2,3-Dioxygenase (IDO), an enzyme that is responsible for converting tryptophan to kynurenines.
Formulation	PBS, pH 7.4 containing 0.09% Sodium Azide as preservative. State: Ig Fraction State: Liquid Ig fraction.
Concentration	lot specific
Purification	Ammonium Sulphate Precipitation
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	indoleamine 2,3-dioxygenase 1
Database Link	Entrez Gene 3620 Human UniProt ID P14902
Background	IDO is expressed by a wide variety of tissues and IDO can be upregulated by interferon gamma. IDO modulates levels of the amino acid tryptophan, which is vital for cell growth, but is also involved in the suppression of the immune response. Reports suggest that IDO is involved in the suppression of the immune response to tumours and blocking the IDO pathway may be a potential target for immunotherapy.
Synonyms	IDO1, IDO, INDO, Indoleamine 2,3-dioxygenase 1, EC=1.13.11.52, Indoleamine 2,3-dioxygenase, IDO, Indoleamine-pyrrole 2,3-dioxygenase
Reference Data

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