SHP2 (PTPN11) Mouse Monoclonal Antibody [Clone ID: OTI1F7]

CAT#: CF501914

Carrier-free (BSA/glycerol-free) PTPN11 mouse monoclonal antibody, clone OTI1F7 (formerly 1F7)

Formulation: Standard Carrier-Free



  View other "OTI1F7" antibodies (4)

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CNY 3,999.00


货期*
2周

规格
    • 100 ug

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Specifications

Product Data
Clone Name OTI1F7
Applications FC, WB
Recommend Dilution WB 1:1000, FLOW 1:100
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Immunogen Full length human recombinant protein of human PTPN11(NP_002825) produced in HEK293T cell.
Formulation Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size 67.8 kDa
Gene Name protein tyrosine phosphatase non-receptor type 11
Background The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq]
Synonyms BPTP3; CFC; JMML; METCDS; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Reference Data
Protein Families Druggable Genome, Phosphatase
Protein Pathways Adipocytokine signaling pathway, Chronic myeloid leukemia, Epithelial cell signaling in Helicobacter pylori infection, Jak-STAT signaling pathway, Leukocyte transendothelial migration, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Renal cell carcinoma
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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