LRPAP1 Mouse Monoclonal Antibody [Clone ID: 7F1]

Specifications

Product Data
Clone Name	7F1
Applications	IF, IHC, WB
Recommend Dilution	Immunoblotting. Immunofluorescence. Immunohistochemistry: 1/20. Ligand-binding assays.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human RAP.
Specificity	This antibody BM5054 (7F1) reacts with the 39 kDa RAP protein, which is cosynthesized with Human LRP/alpha2MR (low density lipoprotein receptor-related protein/alpha2-Macro-Globulin Receptor). It inhibits the binding of ligands, e.g. tPA, uPA, VLDL, liproprotein lipase, and alpha2-Macroglobulin-proteinase complexes to LRP/A2MR.
Formulation	PBS buffer, pH 7.4 containing 0.5% BSA as stabilizer. State: Purified State: Lyophilized purified IgG fraction.
Reconstitution Method	Restore in 1 ml distilled water.
Purification	Affinity Chromatography on Protein A .
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store at 2-8°C. Following reconstitution store the antibody at -20°C. Avoid repeated freezing and thawing.
Gene Name	LDL receptor related protein associated protein 1
Database Link	Entrez Gene 4043 Human UniProt ID P30533
Background	Low density lipoprotein receptor-related protein-associated protein 1 (RAP) interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. It is present on the cell surface forming a complex with the alpha 2 macroglobulin receptor heavy and light chains. Binds LRP1B; binding is followed by internalization and degradation. In complex with the alpha 2 MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis.
Synonyms	Alpha-2-MRAP, RAP
Reference Data

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