Macro H2A.2 (H2AFY2) (N-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, WB
Recommend Dilution	ELISA:  1/1000.  Western Blot: 1/100-1/500.  Flow Cytometry: 1/10-1/50.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 14-43 amino acids from the N-terminal region of Human H2AFY2 / MACROH2A2
Specificity	This antibody recognizes Human and Mouse H2AFY2 / MACROH2A2 (N-term).
Formulation	PBS containing 0.09% (W/V) Sodium Azide as preservative State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein A column, followed by peptide affinity purification
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	H2A histone family member Y2
Database Link	Entrez Gene 404634 MouseEntrez Gene 55506 Human UniProt ID Q9P0M6
Background	Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.
Synonyms	Core histone macro-H2A.2, Histone macroH2A2, mH2A2
Note	Molecular Weight: 40058 Da
Reference Data
Protein Pathways	Systemic lupus erythematosus

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