SIGLECL1 (SIGLEC12) (C-term) Rabbit Polyclonal Antibody
CAT#: AP18196PU-N
SIGLECL1 (SIGLEC12) (C-term) rabbit polyclonal antibody
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CNY 6,160.00
货期*
5周
规格
Specifications
Product Data | |
Applications | WB |
Recommend Dilution | ELISA: 1/1,000. Western blotting: 1/50 - 1/100. |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | KLH conjugated synthetic peptide selected from the C-terminal region of human SIGLEC12 |
Specificity | This antibody reacts to SIGLEC12. |
Formulation | PBS with 0.09% (W/V) sodium azide State: Liquid purified Ig |
Concentration | lot specific |
Purification | Saturated Ammonium Sulfate (SAS) precipitation |
Conjugation | Unconjugated |
Storage Condition | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Gene Name | sialic acid binding Ig like lectin 12 (gene/pseudogene) |
Database Link | |
Background | Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. SIGLEC12 is a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. This protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. |
Synonyms | Siglec-12, SIGLECL1, Siglec-L1, SLG |
Reference Data | |
Protein Families | Druggable Genome, Stem cell - Pluripotency, Transmembrane |
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