Syndecan 1 (SDC1) Mouse Monoclonal Antibody [Clone ID: B-A38]

Specifications

Product Data
Clone Name	B-A38
Applications	FC, IHC
Recommend Dilution	Flow Cytometry.  Immunohistochemistry (1/50).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	U266 cell line. Myeloma X63/AG.8653 x Balb/c spleen cells.
Specificity	The antibody B-A38 recognizes CD138 (Syndecan-1), a 65-70 kDa heparan sulfate proteoglycan expressed mainly in the epidermis and plasma cells, but also in growth factor-stimulated lymphocytes.
Formulation	Azide Free PBS, pH 7.4, 0.2 μm filter sterilized State: Azide Free State: Liquid purified Ig fraction Preservative: None
Concentration	lot specific
Purification	Ion Exchange Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	syndecan 1
Database Link	Entrez Gene 6382 Human UniProt ID P18827
Background	CD138 (syndecan-1) is a transmembrane proteoglycan that can bind a variety of cytokines and modulate their activity, as well as the activity of extracellular matrix components and influence many developmental processes. CD138 is expressed mainly in differentiating keratinocytes and is transiently upregulated in all layers of the epidermis upon tissue injury. It is also highly expressed on plasma cells and can be detected even on fibroblasts, vascular smooth muscle cells and endothelial cells. Up-regulation and down-regulation of CD138 on the cell surface often correlates with the gain of cancerous characteristics. Serum levels of the shedded soluble sCD138 are used as a prognostic factor of cancerogenesis.
Synonyms	SYND1, SDC1, SDC
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways	Cell adhesion molecules (CAMs), ECM-receptor interaction

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