Complement factor B (CFB) (Ba Fragment) Mouse Monoclonal Antibody [Clone ID: 014III-33.2.4.3]

Specifications

Product Data
Clone Name	014III-33.2.4.3
Applications	ELISA, FC, FN, IHC, WB
Recommend Dilution	Western Blot. Functional Assays. Flow Cytometry. ELISA: This antibody binds both the Ba fragment and the whole protein so is not suitable for all ELISA applications. Immunohistochemistry on frozen sections. Recommended Positiv Control: Kidney from post streptoccal glomerulonephritis patients.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified human complement factor b.
Specificity	This antibody recognises the 30kDa Ba fragment of 90kDa complement factor B, present in blood serum.
Formulation	Borate buffered saline pH 8.2 - 8.4 containing 0.02% Sodium Azide State: Purified State: Liquid purified Ig
Concentration	lot specific
Purification	Affinity chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	complement factor B
Database Link	Entrez Gene 629 Human UniProt ID P00751
Background	C3b associates with complement factor B, inducing conformational change. This enables complement factor D to cleave the N-terminal of complement factor B (the Ba subunit), leaving the 63 kDa Bb subunit associated with C3b, forming C3 convertase. Subunit Ba inhibits lymphocyte proliferation. Conversely, subunit Bb is involved in the proliferation of preactivated B lymphocytes.
Synonyms	Properdin factor B, C3/C5 convertase, PBF2, CFB, BF, BFD
Note	This antibody inhibits the function of factor B and binds both nascent factor B and the Ba cleavage product. Removal of Sodium Azide is recommended prior to use in functional assays.
Reference Data
Protein Families	Druggable Genome, Protease, Secreted Protein
Protein Pathways	Complement and coagulation cascades

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