LOX Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, IHC, IP, WB
Recommend Dilution	Immunohistochemistry, Knockout Validated, Immunocytochemistry/ Immunofluorescence: 1:10-1:500, Immunoprecipitation: 1:10-1:500, Western Blot: 1:100-1:2000, Immunohistochemistry-Paraffin: 1:10-1:500, Immunohistochemistry-Frozen
Reactivity	Human, Mouse, Rat, Bovine, Primate
Host	Rabbit
Clonality	Polyclonal
Immunogen	Within the range of amino acids 305-338 of human LOX protein were used as the immunogen.
Formulation	Crude whole Rabbit sera with 50% Glycerol, 0.025% Sodium Azide
Concentration	lot specific
Purification	Whole antisera
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	lysyl oxidase
Database Link	NP_002308 Entrez Gene 16948 MouseEntrez Gene 24914 RatEntrez Gene 4015 Human UniProt ID P28300
Background	LOX (lysyl oxidase) is a copper-dependent amine oxidase enzyme responsible for post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. LOX is synthesized as an inactive 50 kD proenzyme that is N-glycosylated in ER/Golgi complex and then secreted into extracellular environment, where it is processed by pro-collagen C-proteinases (mammalian Tolloids and BMP-1) into an active enzyme (28-32 kD) and an 18 kD propeptide (LOX-PP) which can be N-glycosylated intracellularly into a ~35 kD form. LOX activity is critical in maintaining the tensile as well as elastic features of the connective tissues of skeletal, pulmonary and cardiovascular systems. LOX deficiency leads to intra-gestational lethality in LOX-/- mice wherein the pups exhibits aortic aneurysms/tortuosity/rupture. LOX expression is highly regulated during normal development; and, its aberrant expression or activity has been documented in a range of diseases predominantly associated with the ECM such as Cutis laxa or OHS (occipital horn syndrome), Menkes' syndrome, myocardial ischaemia/heart failure, atherosclerosis, scleroderma, liver cirrhosis, Pseudoexfoliation syndrome and glaucoma, Alzheimer's/non-Alzheimer's dementia, Wilson's disease, primary biliary cirrhosis as well as in many type of cancers, wherein LOX implicates in promoting tumor cell invasion and metastasis.
Synonyms	MGC105112
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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