QRICH1 (NM_017730) Human Mass Spec Standard

CAT#: PH313114

QRICH1 MS Standard C13 and N15-labeled recombinant protein (NP_060200)



  View other "QRICH1" proteins (5)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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经常一起买 (2)
QRICH1 Antibody - middle region
    • 50 ug

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Transient overexpression lysate of glutamine-rich 1 (QRICH1), transcript variant 2
    • 100 ug

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Specifications

Product Data
Description QRICH1 MS Standard C13 and N15-labeled recombinant protein (NP_060200)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC213114
Predicted MW 86.4 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_060200
RefSeq Size 3331
RefSeq ORF 2328
Synonyms AB-DIP; VERBRAS
Locus ID 54870
Cytogenetics 3p21.31
Summary Transcriptional regulator that acts as a mediator of the integrated stress response (ISR) through transcriptional control of protein homeostasis under conditions of ER stress (PubMed:33384352). Controls the outcome of the unfolded protein response (UPR) which is an ER-stress response pathway (PubMed:33384352). ER stress induces QRICH1 translation by a ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced QRICH1 regulates a transcriptional program associated with protein translation, protein secretion-mediated proteotoxicity and cell death during the terminal UPR (PubMed:33384352). May cooperate with ATF4 transcription factor signaling to regulate ER homeostasis which is critical for cell viability (PubMed:33384352). Upregulates CASP3/caspase-3 activity in epithelial cells under ER stress. Central regulator of proteotoxicity associated with ER stress-mediated inflammatory diseases in the intestines and liver (PubMed:33384352). Involved in chondrocyte hypertrophy, a process required for normal longitudinal bone growth (PubMed:30281152).[UniProtKB/Swiss-Prot Function]
Protein Families Druggable Genome
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