Factor X (F10) (NM_000504) Human Mass Spec Standard

CAT#: PH308506

F10 MS Standard C13 and N15-labeled recombinant protein (NP_000495)



  View other "Factor X" proteins (4)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Transient overexpression lysate of coagulation factor X (F10)
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Specifications

Product Data
Description F10 MS Standard C13 and N15-labeled recombinant protein (NP_000495)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC208506
Predicted MW 54.7 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_000495
RefSeq Size 1560
RefSeq ORF 1464
Synonyms FX; FXA
Locus ID 2159
Cytogenetics 13q34
Summary This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015]
Protein Families Druggable Genome, Protease, Transmembrane
Protein Pathways Complement and coagulation cascades
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