alpha 2 Macroglobulin (A2M) (NM_000014) Human Mass Spec Standard

CAT#: PH307905

A2M MS Standard C13 and N15-labeled recombinant protein (NP_000005)



  View other "alpha 2 Macroglobulin" proteins (4)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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经常一起买 (2)
Transient overexpression lysate of alpha-2-macroglobulin (A2M)
    • 100 ug

CNY 3,080.00


A2M rabbit polyclonal antibody
    • 25 ul

CNY 800.00
CNY 1,280.00

Specifications

Product Data
Description A2M MS Standard C13 and N15-labeled recombinant protein (NP_000005)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC207905
Predicted MW 163.3 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_000005
RefSeq Size 4678
RefSeq ORF 4422
Synonyms A2MD; CPAMD5; FWP007; S863-7
Locus ID 2
Cytogenetics 12p13.31
Summary The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Complement and coagulation cascades
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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