Factor XIIIa (F13A1) (NM_000129) Human Mass Spec Standard

CAT#: PH306464

F13A1 MS Standard C13 and N15-labeled recombinant protein (NP_000120)



  View other "Factor XIIIa" proteins (3)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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经常一起买 (2)
Transient overexpression lysate of coagulation factor XIII, A1 polypeptide (F13A1)
    • 100 ug

CNY 3,080.00


F13A1 (Factor XIIIa) mouse monoclonal antibody, clone OTI6F5 (formerly 6F5)
    • 100 ul

CNY 1,999.00
CNY 2,700.00

Specifications

Product Data
Description F13A1 MS Standard C13 and N15-labeled recombinant protein (NP_000120)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC206464
Predicted MW 83.3 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_000120
RefSeq Size 3863
RefSeq ORF 2196
Synonyms F13A
Locus ID 2162
Cytogenetics 6p25.1
Summary This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Complement and coagulation cascades
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