Rad6 (UBE2A) (NM_003336) Human Mass Spec Standard

Specifications

Product Data
Description	UBE2A MS Standard C13 and N15-labeled recombinant protein (NP_003327)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC204194
Predicted MW	17.3 kDa
Protein Sequence	Sequence Link (showhide) >RC204194 protein sequence Red=Cloning site Green=Tags(s) MSTPARRRLMRDFKRLQEDPPAGVSGAPSENNIMVWNAVIFGPEGTPFEDGTFKLTIEFTEEYPNKPPTV RFVSKMFHPNVYADGSICLDILQNRWSPTYDVSSILTSIQSLLDEPNPNSPANSQAAQLYQENKREYEKR VSAIVEQSWRDC TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_003327
RefSeq Size	1878
RefSeq ORF	456
Synonyms	HHR6A; MRXS30; MRXSN; RAD6A; UBC2
Locus ID	7319
Cytogenetics	Xq24
Summary	The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair, and may play a role in transcriptional regulation. Mutations in this gene are associated with cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Protein Families	Druggable Genome
Protein Pathways	Ubiquitin mediated proteolysis

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