OGDH (NM_002541) Human Mass Spec Standard

CAT#: PH300446

OGDH MS Standard C13 and N15-labeled recombinant protein (NP_002532)



  View other "OGDH" proteins (6)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Specifications

Product Data
Description OGDH MS Standard C13 and N15-labeled recombinant protein (NP_002532)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC200446
Predicted MW 115.9 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_002532
RefSeq Size 4319
RefSeq ORF 3069
Synonyms AKGDH; E1k; KGD1; OGDC; OGDH2
Locus ID 4967
Cytogenetics 7p13
Summary This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]
Protein Families Druggable Genome
Protein Pathways Citrate cycle (TCA cycle), Lysine degradation, Metabolic pathways, Tryptophan metabolism
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